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KMID : 0383819890360020134
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Tuberculosis and Respiratory Diseases
1989 Volume.36 No. 2 p.134 ~ p.141
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Autoradiographic Labeling Index of Tritiated Thymidine in Human Lung Cancer
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박성수/Sung Soo Park
이성준/이동후/이정회/이중달/Seong Jun Lee/Dong Hoo Lee/Jung Hee Lee/Jung Dal Lee
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Abstract
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For the assessment of tumor cell proliferation, in vitro thymidine labeling indices of
human lung cancers and squamous metaplasia were measured employing autoradiography
of paraffin-embedded tissue sections.
The tissues for culture were obtained with fiberoptic bronchosceopic biopsy from the
19 patients. The biopsy specimens consisted of eight squamous cell carcinomas, five
small cell carcinomas, and six squamous metaplasias. The biopsy specimens were
incubated with Eagle's MEM culture media containing tritiated thymidine (specific
activity, 20 Ci/mmol) for 30 minutes.
The mean value with standard deviation of thymidine labeling indices was 20.54±
5.57% for squamous cell carcinomas, 19.20±5.19% for small cell carcinomas and 7.94±
2.29% for squamous metaplasias, respectively. A wide range of individual labeling
indices was noticed in the lung cancers.
In conclusion, tritiated thymidine labeling indices of human lung cancers were
significantly higher than those of squamous metaplasia that may probably be an
preneoplastic lesion.
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